تفاعل #65573

معادلة التفاعل

4-phenylcyclohexanone

cyclohexylmethylamine

water

→

N-(4-phenylcyclohexyl)-N-cyclohexylmethylamine

المذيبات

benzene

ظروف التفاعل

المعالجة

1. 1
   workup.DISTILLATIONthe solvent was distilled away in vacuo
2. 2
   workup.DISSOLUTIONThe residue was dissolved in methanol and to the solution
3. 3
   workup.ADDITIONwas added 1.5 g of sodium borohydride
4. 4
   workup.DISTILLATIONthe solvent was distilled away in vacuo
5. 5
   workup.ADDITIONTo the residue was added water
6. 6
   استخلاصextracted with diethyl ether
7. 7
   غسيلThe organic layer was washed with saturated brine
8. 8
   تجفيفdried over magnesium sulfate
9. 9
   workup.DISTILLATIONThe solvent was distilled away

الإجراء التجريبي

A solution of 5 g of 4-phenylcyclohexanone and cyclohexylmethylamine in 100 ml of benzene was refluxed for 2 hours with removing water and the solvent was distilled away in vacuo. The residue was dissolved in methanol and to the solution was added 1.5 g of sodium borohydride. The mixture was stirred at room temperature and the solvent was distilled away in vacuo. To the residue was added water and extracted with diethyl ether. The organic layer was washed with saturated brine and dried over magnesium sulfate. The solvent was distilled away to give 7 g of N-(4-phenylcyclohexyl)-N-cyclohexylmethylamine as an oil. (N-(4-phenylcyclohexyl)-N-cyclohexylmethylamine hydrochloride, melting at 267°-270° C. with decomposition)

المصدر