تفاعل #654069

معادلة التفاعل

ammonium chloride

phenylmagnesium bromide

aldehyde

(3β,5α,20S)-3-(benzoyloxy)-4,4-dimethylpregna-8,14-diene-20-carboxaldehyde

→

(3β,5α,20S)-4,4,20-trimethyl-21-phenylpregna-8,14-diene-3,21-diol 3-benzoate

المذيبات

tetrahydrofuran

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe product was extracted into ethyl acetate
2. 2
   غسيلThe combined organic phases were washed with water
3. 3
   تجفيفdried over sodium sulfate
4. 4
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

ix)—A solution of the aldehyde 10 (2.0 g), obtained in the previous step, in dry tetrahydrofuran (17 ml) was added dropwise to a 1 M solution of phenylmagnesium bromide (13 ml) in tetrahydrofuran. The reaction mixture was stirred at room temperature for 3 h. A saturated aqueous solution of ammonium chloride was added and the product was extracted into ethyl acetate. The combined organic phases were washed with water, dried over sodium sulfate, and concentrated under reduced pressure to give (3β,5α,20S)-4,4,20-trimethyl-21-phenylpregna-8,14-diene-3,21-diol 3-benzoate (11) (3.0 g) which was used in the following step without further purification.

المصدر