تفاعل #654026

معادلة التفاعل

3-nitrophthalonitrile

2,2,3,3,3-pentafluoropropanol

potassium carbonate

dimethyl sulfoxide

→

intended compound

المردود 95.1%

3-(2,2,3,3,3-pentafluoropropoxy)phthalonitrile

المردود 95.1%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGAfter stirring at 50° C. for 4 hours
2. 2
   أخرىThe reaction liquid
3. 3
   درجة الحرارةwas cooled
4. 4
   أخرىthe precipitated crystal was collected
5. 5
   أخرىdried

الإجراء التجريبي

A reaction flask was loaded with 8.7 g of 3-nitrophthalonitrile, 9.0 g of 2,2,3,3,3-pentafluoropropanol, 13.8 g of anhydrous potassium carbonate, and 350 ml of dimethyl sulfoxide, and the temperature was raised to 50° C. with stirring under nitrogen flow. After stirring at 50° C. for 4 hours, the heating was stopped. The reaction liquid was cooled and added into 500 ml of water, and the precipitated crystal was collected and dried to yield 13.2 g of the intended compound.

المصدر