تفاعل #653891

معادلة التفاعل

6-bromo-[2,4′]bipyridine

(S)-2-amino-3-phenylpropylamine

→

6-((S)-2-Amino-3-phenylpropylamino)-2-(4-pyridyl)pyridine

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction was cooled to rt
2. 2
   أخرىpurified (SiO2, CH2Cl2/MeOH/NH4OH: 100/11/8)
3. 3
   أخرىto give the step 1 compound
4. 4
   أخرى(This reaction provides major products wherein the

الإجراء التجريبي

A neat mixture of 6-bromo-[2,4′]bipyridine (2.35 gm, 10 mmole) and (S)-2-amino-3-phenylpropylamine (3 gm, 20 mmole) was heated to 190° C. for 4 hr. The reaction was cooled to rt and purified (SiO2, CH2Cl2/MeOH/NH4OH: 100/11/8) to give the step 1 compound. (This reaction provides major products wherein the less hindered amine functionality displaces the bromide,when the nucleophile is an alkyldiamine) MS (m/z): Calcd. C19H20N4 (M+): 304, found (M+H)+: 305.2.

المصدر