تفاعل #65389

معادلة التفاعل

2-(6-amino-3,4-dihydro-2,2-dimethyl-2H-1,4-benzoxazin-4-yl)pyridine N-oxide

acetic anhydride

→

2-(6-acetamido-3,4-dihydro-2,2-dimethyl-2H-1,4-benzoxazin-4-yl)pyridine N-oxide

ظروف التفاعل

المعالجة

1. 1
   تركيزAfter concentration
2. 2
   workup.DISSOLUTIONthe residue was dissolved in chloroform
3. 3
   غسيلwashed with saturated aqueous sodium hydrogen carbonate solution
4. 4
   أخرىdried
5. 5
   تركيزconcentrated
6. 6
   أخرىThe residue was recrystallized from chloroform-ether

الإجراء التجريبي

To a solution of 0.474 g of 2-(6-amino-3,4-dihydro-2,2-dimethyl-2H-1,4-benzoxazin-4-yl)pyridine N-oxide in 5 ml of acetic anhydride was added 3 drops of pyridine and the mixture was stirred at room temperature for 63 hours. After concentration, the residue was dissolved in chloroform, washed with saturated aqueous sodium hydrogen carbonate solution, dried and concentrated. The residue was recrystallized from chloroform-ether to give 0.285 g of 2-(6-acetamido-3,4-dihydro-2,2-dimethyl-2H-1,4-benzoxazin-4-yl)pyridine N-oxide.

المصدر