تفاعل #65352

معادلة التفاعل

6-chloropurine

cyclopropylamine

→

cream solid

المردود 153.1%

6-Cyclopropylamino-9H-purine

المردود 153.1%

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was removed
2. 2
   أخرىthe crude product was purified on a silica gel column
3. 3
   غسيلeluting with CHCl3

الإجراء التجريبي

A solution of 6-chloropurine (Aldrich Chemical Company, 4.23 g, 27 mmoles) and cyclopropylamine (Aldrich Chemical Company, 12.5 g, 22 mmoles) in MeOH (100 ml) was heated at 50° C. for 48 hours. The solvent was removed, and the crude product was purified on a silica gel column eluting with CHCl3 : 5% MeOH to obtain 5.90 g of a cream solid. This was recrystallized from MeOH to give two crops, 2.69 g and 1.16 g (81.4% total yield); mp. 237-240.

المصدر