تفاعل #653203

معادلة التفاعل

hydrochloric acid

methyl (E)-3-[5-(4-methylphenyl)furan-2-yl]acrylate

sodium hydroxide

→

(E)-3-[5-(4-methylphenyl)furan-2-yl]acrylic acid

المردود 66.3%

المذيبات

tetrahydrofuran-ethanol

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe mixture was extracted with ethyl acetate
2. 2
   غسيلThe organic layer was washed with saturated sodium chloride solution
3. 3
   تجفيفdried with magnesium sulfate
4. 4
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

To a solution of methyl (E)-3-[5-(4-methylphenyl)furan-2-yl]acrylate (1.49 g) in tetrahydrofuran-ethanol (10-10 ml) was added 2N sodium hydroxide (4 ml) at room temperature, and the mixture was stirred for 24 hours. The reaction mixture was acidified with 1N hydrochloric acid, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated sodium chloride solution, dried with magnesium sulfate and concentrated under reduced pressure to give (E)-3-[5-(4-methylphenyl)furan-2-yl]acrylic acid (0.93 g) as colorless crystals.

المصدر