تفاعل #65206

معادلة التفاعل

6-(2-chlorobenzoyl)-5-(2-chlorobenzoylamino)indan

ammonia

→

5-amino-6-(2-chlorobenzoyl)indan

المردود 94.4%

المذيبات

H2SO4

—

ice water

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with ethyl acetate
2. 2
   غسيلThe extract was washed with water
3. 3
   تجفيفdried (MgSO4)
4. 4
   workup.DISTILLATIONthe solvent was distilled off

الإجراء التجريبي

A mixture of 6-(2-chlorobenzoyl)-5-(2-chlorobenzoylamino)indan (16.0 g) and 70% H2SO4 (100 ml) was heated at 120° C. for 30 minutes and, then, poured in ice-water (300 ml). The solution was alkalinized with concentrated aqueous ammonia and extracted with ethyl acetate. The extract was washed with water and dried (MgSO4) and the solvent was distilled off to give 5-amino-6-(2-chlorobenzoyl)indan as yellow oil (10.0 g, 94.3%). Recrystallization from hexane gave yellow prisms, m.p. 90°-92°.

المصدر