تفاعل #65205

معادلة التفاعل

HCl

5-(2-chlorobenzoylamino)indan

2-chlorobenzoyl chloride

tin tetrachloride

→

6-(2-chlorobenzoyl)-5-(2-chlorobenzoylamino)indan

المردود 66.2%

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   أخرىThe organic layer was separated
2. 2
   غسيلwashed with water, 2N NaOH and water in the order
3. 3
   workup.DISTILLATIONthe solvent was distilled off
4. 4
   أخرىThe residue was chromatographed on silica gel
5. 5
   غسيلeluted with hexane-acetone (4:1)

الإجراء التجريبي

A mixture of 5-(2-chlorobenzoylamino)indan (16 g), 2-chlorobenzoyl chloride (15.5 g) and tin tetrachloride (10.2 ml) was heated at 130° C. for 30 minutes and, then, diluted with ethyl acetate (150 ml), followed by addition of 3N HCl (150 ml). The organic layer was separated and washed with water, 2N NaOH and water in the order mentioned and the solvent was distilled off. The residue was chromatographed on silica gel and eluted with hexane-acetone (4:1) to give 6-(2-chlorobenzoyl)-5-(2-chlorobenzoylamino)indan as oil (16.0 g, 66.2%).

المصدر