تفاعل #651853

معادلة التفاعل

N-methylpyrrolidone

2-(trans-4-propylcyclohexyl)ethenyl bromide

copper cyanide

→

oily product

3-(trans-4-propylcyclohexyl)acrylonitrile

المذيبات

hydrochloric acid

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   درجة الحرارةunder reflux
3. 3
   درجة الحرارةby heating for 7 hours
4. 4
   استخلاصextracted with toluene
5. 5
   أخرىThe organic layer thus obtained
6. 6
   غسيلwas washed with water
7. 7
   أخرىdried
8. 8
   تركيزconcentrated under a reduced pressure
9. 9
   أخرىto obtain a brown oily product
10. 10
    أخرىThis product was isolated
11. 11
    أخرىpurified

الإجراء التجريبي

To 30 ml of N-methylpyrrolidone was dissolved 3 g of 2-(trans-4-propylcyclohexyl)ethenyl bromide, 2 g of copper cyanide was added thereto, and then stirred under reflux by heating for 7 hours. A solution of ferric chloride in 6N hydrochloric acid was added to the reaction liquid, and extracted with toluene. The organic layer thus obtained was washed with water, dried, and then concentrated under a reduced pressure to obtain a brown oily product. This product was isolated and purified by using silica gel column chromatography to obtain 1.5 g of an oily product. As a result of various instrumental analysises, the product was confirmed to be the subject compound.

المصدر