تفاعل #65176

معادلة التفاعل

2,4-dichlorobenzaldehyde

3-pyridylacetonitrile

K2CO3

→

title compound

المردود 76.0%

2-(3-pyridyl)-3-(2,4-dichlorophenyl)-2-propenenitrile

المردود 76.0%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىa white solid precipitated out of the reaction mixture
2. 2
   workup.STIRRINGThe reaction mixture was stirred overnight
3. 3
   ترشيحfiltered
4. 4
   غسيلThe filter cake was washed with absolute ethanol
5. 5
   workup.DISSOLUTIONdissolve in CH2Cl2
6. 6
   ترشيحThe CH2Cl2 solution was filtered
7. 7
   تركيزconcentrated in vacuo
8. 8
   أخرىThe resulting white solid was recrystallized from 3:2 hexane/ethyl acetate

الإجراء التجريبي

To a stirred solution of 2,4-dichlorobenzaldehyde (5.0 g, 29 mmole) and 3-pyridylacetonitrile (3.05 ml, 29 mmole) in 150 ml absolute ethanol were added 3.95 g K2CO3. After stirring for about 15 minutes, a white solid precipitated out of the reaction mixture. The reaction mixture was stirred overnight and filtered. The filter cake was washed with absolute ethanol and dissolve in CH2Cl2. The CH2Cl2 solution was filtered and concentrated in vacuo. The resulting white solid was recrystallized from 3:2 hexane/ethyl acetate to give 6.0 g (76%) of the title compound.

المصدر