تفاعل #65152

معادلة التفاعل

3-bromo-3,4-dihydro-2,2-dimethyl-6-pentafluoroethyl-2H-1-benzopyran-4-ol

potassium hydroxide

→

3,4-dihydro-2,2-dimethyl-3,4-epoxy-6-pentafluoroethyl-2H-1-benzopyran

المردود 96.2%

المذيبات

diethyl ether

ظروف التفاعل

المعالجة

1. 1
   أخرىsynthesized
2. 2
   workup.ADDITIONwas added
3. 3
   أخرىThe insoluble material was removed by filtration
4. 4
   أخرىthe solvent was removed by distillation under reduced pressure

الإجراء التجريبي

To 1.5 l of diethyl ether was added 12.63 g (33.67 mmol) of 3-bromo-3,4-dihydro-2,2-dimethyl-6-pentafluoroethyl-2H-1-benzopyran-4-ol synthesized according to the process of JP-B-2-237985, and 30.2 g of potassium hydroxide was added thereto, followed by stirring at room temperature for 54 hours. The insoluble material was removed by filtration, and the solvent was removed by distillation under reduced pressure to yield 9.5 g (96.2%) of 3,4-dihydro-2,2-dimethyl-3,4-epoxy-6-pentafluoroethyl-2H-1-benzopyran.

المصدر