تفاعل #65100

معادلة التفاعل

4-methoxy-3-fluoro-benzene boronic acid

4-bromo-4'-cyanobiphenyl

sodium carbonate

benzene

→

4-methoxy-3-fluoro-4"-cyano-p-terphenyl

المردود 88.6%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىa solution which was prepared
2. 2
   workup.ADDITIONwas slowly added dropwise
3. 3
   درجة الحرارةto reflux for 8 hours
4. 4
   درجة الحرارةthe solution was cooled
5. 5
   أخرىthe crystals thus precipitated
6. 6
   أخرىwere separated by filtration
7. 7
   غسيلwashed with water and methanol in turn
8. 8
   أخرىdried

الإجراء التجريبي

To a mixture of 2.4 g of 4-bromo-4'-cyanobiphenyl, 0.37 g of tetrakis(triphenylphosphine)palladium(0), 15.2 ml of a 2N aqueous sodium carbonate solution, and 19.4 ml of benzene, a solution which was prepared by dissolving 1.9 g of 4-methoxy-3-fluoro-benzene boronic acid synthesized in [1] above in 14.4 ml of ethanol was slowly added dropwise with stirring, and the solution was subjected to reflux for 8 hours. After the reflux was finished, the solution was cooled, and the crystals thus precipitated were separated by filtration and washed with water and methanol in turn, and dried to obtain 2.5 g of 4-methoxy-3-fluoro-4"-cyano-p-terphenyl.

المصدر