تفاعل #65097

معادلة التفاعل

hydrochloric acid

4-n-octyloxy-2', 3'-difluorobiphenyl

butyllithium

triisopropylborate

→

4-(p-n-octyloxyphenyl)-2,3-difluorobenzene boronic acid

المردود 73.4%

المذيبات

THF

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىthe solution thus formed
2. 2
   workup.STIRRINGAfter the solution was stirred at an ambient temperature for 12 hours
3. 3
   workup.STIRRINGfurther stirred for 1 hour

الإجراء التجريبي

After 2.72 g of the 4-n-octyloxy-2', 3'-difluorobiphenyl was dissolved in 20 ml of a dried THF, the solution thus formed was cooled down to -70° C. under a nitrogen atmosphere and added dropwise with 5.5 ml of butyllithium (1.6 mol/liter hexane solution). The solution was continuously stirred at the same temperature for 2 hours, and then added dropwise with a THF solution containing 3.21 g of triisopropylborate. After the solution was stirred at an ambient temperature for 12 hours, it was added with 7.7 ml of a 10% aqueous hydrochloric acid solution and further stirred for 1 hour. Then, the same after-treatments as in [1] in Example 1 were repeated to obtain 2.27 g of 4-(p-n-octyloxyphenyl)-2,3-difluorobenzene boronic acid.

المصدر