تفاعل #65084

معادلة التفاعل

2-(4-tetrahydropyranyloxy-2-butynyl)cyclopropylmethyl t-butyldimethylsilyl ether

tetrabutyl ammonium fluoride

→

2-(4-tetrahydropyranyloxy-2-butynyl)cyclopropylmethanol

المردود 111.5%

المذيبات

tetrahydrofuran

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   أخرىat 0° C
2. 2
   أخرىThe product was purified by column chromatography

الإجراء التجريبي

The 2-(4-tetrahydropyranyloxy-2-butynyl)cyclopropylmethyl t-butyldimethylsilyl ether (5.8 g, 17.2 mmol) was dissolved in tetrahydrofuran (50 ml), and a tetrabutyl ammonium fluoride (factor=1.0) tetrahydrofuran solution (33 ml, 33 mmol) was added thereto at 0° C. The mixture was stirred for one hour. The product was purified by column chromatography to obtain 2-(4-tetrahydropyranyloxy-2-butynyl)cyclopropylmethanol (4.3 g).

المصدر