تفاعل #6508

معادلة التفاعل

Benzyl-glycolic Acid

Glycolic acid

N,N'-diisopropylbenzylisourea

→

benzyl glycolate

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGthe mixture stirred for 48 h at room temperature
2. 2
   أخرىthe diisopropylurea is removed by filtration
3. 3
   أخرىthe THF evaporated under reduced pressure
4. 4
   workup.WAITThe resulting product is pumped under high vacuum for 24 h

الإجراء التجريبي

Construction of Benzyl-glycolic Acid. Glycolic acid (7.69,100 mmols) is added to N,N'-diisopropylbenzylisourea (23.39,100 mmols) with stirring for 1 hour. The volume is then increased to 200 mL with THF, and the mixture stirred for 48 h at room temperature. After cooling the mixture to -15° C., the diisopropylurea is removed by filtration and the THF evaporated under reduced pressure. The resulting product is pumped under high vacuum for 24 h to give benzyl glycolate which may be used without further purification.

المصدر