تفاعل #65059

معادلة التفاعل

urea

4-Fluoroaniline

sulphuric acid

sodium nitrite

→

4-Fluorobenzenediazonium hydrogensulphate

المذيبات

water

water

ظروف التفاعل

المعالجة

1. 1
   أخرىA smooth paste was formed
2. 2
   درجة الحرارةThe mixture was cooled to <5°
3. 3
   درجة الحرارةwhile maintaining the temperature at <5° with external cooling
4. 4
   أخرىA clear red solution was obtained
5. 5
   workup.ADDITIONwas added
6. 6
   أخرىto destroy the excess nitrous acid

الإجراء التجريبي

4-Fluoroaniline (11.2 g; 0.1 mol) was added dropwise into a solution of sulphuric acid (25 g) in water (60 ml) over 10 min. A smooth paste was formed. The mixture was cooled to <5° and a solution of sodium nitrite (7.8 g; 0.11 mol) in water (25 ml) was added dropwise over 0.5 hours while maintaining the temperature at <5° with external cooling. A clear red solution was obtained. The solution was stirred for 0.25 hours to complete the reaction and urea (1.0 g) was added to destroy the excess nitrous acid. The resulting solution was used directly in the next stage.

المصدر