تفاعل #64997

معادلة التفاعل

4-chloro-4'-nitrobenzophenone

→

desired product

المردود 79.2%

4-amino-4'-chloro-benzophenone

المردود 79.2%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحwas filtered
2. 2
   أخرىevaporated
3. 3
   أخرىpurified by flash column chromatography (2-8% EtOAc/CH2C12)

الإجراء التجريبي

A suspension of 14.4g (54.8 mmol) of 4-chloro-4'-nitrobenzophenone and 66.9 mg, (0.5 mole %) of platinum oxide was stirred under hydrogen in 300 ml of ethanol for 2 hours The mixture was filtered, evaporated and purified by flash column chromatography (2-8% EtOAc/CH2C12) to obtain 10.05 g (72%) of the desired product as a yellow solid. 1H nmr (CDCl3) δ4.16 (2H, br s), 6.67 (2H, d), 7.43 (2H, d), 7.68 (2H, d), 7.69 (2H, d).

المصدر