تفاعل #64952

معادلة التفاعل

1-methyl-pyridinium-2,3-dicarboxylic acid N-benzylimide iodide

hydrogen

→

6-Benzyl-1-methyl-5,7-dioxo-octahydropyrrolo[3,4-b]pyridine

المذيبات

glycol monomethyl ether

ظروف التفاعل

المعالجة

1. 1
   أخرى(51 hours)
2. 2
   ترشيحThe catalyst is then filtered off
3. 3
   تركيزthe filtrate is concentrated
4. 4
   غسيلthe solution is washed 2× with 300 ml of 10% strength sodium carbonate solution each time
5. 5
   تجفيفAfter drying over sodium sulphate, it
6. 6
   تركيزis concentrated

الإجراء التجريبي

38 g (0.1 mol) of 1-methyl-pyridinium-2,3-dicarboxylic acid N-benzylimide iodide are hydrogenated over 1 g of platinum oxide in 450 ml of glycol monomethyl ether at 30° C. under 70 bar until the uptake of hydrogen has ended (51 hours). The catalyst is then filtered off, the filtrate is concentrated, the residue is taken up in 300 ml of chloroform and the solution is washed 2× with 300 ml of 10% strength sodium carbonate solution each time and with 300 ml of water. After drying over sodium sulphate, it is concentrated. 27 g of an oily residue remain.

المصدر