تفاعل #649387

معادلة التفاعل

5-(5-acetyl-3-thienyl)-3-[1-(ethylsulfonyl)-4-piperidinyl]-1H-indole-7-carboxamide

sodium cyanoborohydride

pyrrolidine

→

title compound

3-[1-(ethylsulfonyl)-4-piperidinyl]-5-{5-[(1S)-1-(1-pyrrolidinyl)ethyl]-3-thienyl}-1H-indole-7-carboxamide

ظروف التفاعل

المعالجة

1. 1
   أخرىThe resulting mixture was reacted in a microwave for 40 min at 150° C
2. 2
   أخرىAll the solvent was evaporated
3. 3
   أخرىthe crude product was partitioned between ethyl acetate (1.5 mL) and 1 M sodium hydroxide (0.2 mL)
4. 4
   أخرىThe reaction was purified by SFC

الإجراء التجريبي

To 5-(5-acetyl-3-thienyl)-3-[1-(ethylsulfonyl)-4-piperidinyl]-1H-indole-7-carboxamide (10 mg, 0.02 mmol) was added sodium cyanoborohydride (7.5 mg, 0.12 mmol) and pyrrolidine (0.03 mL, 0.30 mmol). The resulting mixture was reacted in a microwave for 40 min at 150° C. All the solvent was evaporated and the crude product was partitioned between ethyl acetate (1.5 mL) and 1 M sodium hydroxide (0.2 mL). The reaction was purified by SFC to give the title compound as 100% chirally pure.

المصدر