تفاعل #64935

معادلة التفاعل

1-benzyl-4-hydroxy-3-(2-hydroxyethylamino)-pyrrolidine

sodium hydroxide

→

8-Benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane

المذيبات

sulphuric acid

water

ظروف التفاعل

المعالجة

1. 1
   أخرىthe sodium sulphate which has precipitated
2. 2
   ترشيحis filtered off with suction
3. 3
   استخلاصthe filtrate is extracted with chloroform
4. 4
   تجفيفThe extract is dried over potassium carbonate
5. 5
   تركيزconcentrated
6. 6
   workup.DISTILLATIONthe residue is distilled

الإجراء التجريبي

15.6 g (66mmol) of 1-benzyl-4-hydroxy-3-(2-hydroxyethylamino)-pyrrolidine are heated under reflux in a mixture of 60 ml of concentrated sulphuric acid and 20 ml of water for 6 hours. The mixture is rendered alkaline with concentrated sodium hydroxide solution, the sodium sulphate which has precipitated is filtered off with suction and the filtrate is extracted with chloroform. The extract is dried over potassium carbonate and concentrated and the residue is distilled.

المصدر