تفاعل #649255

معادلة التفاعل

Sodium triacetoxyborohydride

3-[1-(ethylsulfonyl)-4-piperidinyl]-5-(5-formyl-3-thienyl)-1H-indole-7-carboxamide

2-phenylpyrrolidine

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title compound

المردود 22.1%

3-[1-(ethylsulfonyl)-4-piperidinyl]-5-{5-[(2-phenyl-1-pyrrolidinyl)methyl]-3-thienyl}-1H-indole-7-carboxamide

المردود 22.1%

المذيبات

DMSO

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction mixture was then reacted in a microwave at 120° C. for 10 min
2. 2
   أخرىthe reaction was reacted at room temperature overnight
3. 3
   أخرىIt was then purified by Gilson Preparatory HPLC

الإجراء التجريبي

To a solution of 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-(5-formyl-3-thienyl)-1H-indole-7-carboxamide (50 mg, 0.11 mmol) in DMSO (2.0 mL) was added 2-phenylpyrrolidine (147 mg, 1.0 mmol). The reaction mixture was then reacted in a microwave at 120° C. for 10 min. Sodium triacetoxyborohydride (220 mg, 1.0 mmol) was then added and the reaction was reacted at room temperature overnight. It was then purified by Gilson Preparatory HPLC to give 14.0 mg of the title compound (22%).

المصدر