تفاعل #64867

معادلة التفاعل

2,2-difluoro-3-phthalimido-1-tetrahydropyranyloxypropane

paratoluene sulfonic acid

→

2,2-DIFLUORO-3-PHTHALIMIDO-1-PROPANOL

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   تركيزThen the mixture was concentrated in vacuo
2. 2
   workup.ADDITIONdiluted with ethyl acetate
3. 3
   أخرىThe organic phase was separated
4. 4
   تجفيفdried over magnesium sulfate
5. 5
   تركيزconcentrated in vacuo
6. 6
   أخرىThe crude alcohol 2,2-difluoro-3-phthalimido-1-propanol (1.4 g) was used for the next step without further purification

الإجراء التجريبي

A solution of 2,2-difluoro-3-phthalimido-1-tetrahydropyranyloxypropane (2 g, 6.15 mmol), paratoluene sulfonic acid (0.1 g) in absolute ethanol was stirred overnight at room temperature. Then the mixture was concentrated in vacuo, diluted with ethyl acetate and .,washed with brine. The organic phase was separated, dried over magnesium sulfate and concentrated in vacuo. The crude alcohol 2,2-difluoro-3-phthalimido-1-propanol (1.4 g) was used for the next step without further purification.

المصدر