تفاعل #64717

معادلة التفاعل

hydrogencarbonate

methanol

Compound 2

2-[Bis(4-acetoxyphenyl)methyl]-N-(2,4-dimethoxyphenyl)benzamide

→

desired product

المردود 56.0%

2-[Bis(4-hydroxyphenyl)methyl]-N-(2,4-dimethoxyphenyl)benzamide

المردود 56.0%

المذيبات

sodium

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe suspension was heated
2. 2
   درجة الحرارةunder reflux for 30 minutes
3. 3
   تركيزThe resulting mixture was concentrated under reduced pressure, and water
4. 4
   workup.ADDITIONwas added to the residue
5. 5
   استخلاصThe resulting mixture was extracted with ethyl acetate
6. 6
   تجفيفthe extract was dried over anhydrous magnesium sulfate
7. 7
   تركيزAfter concentration under reduced pressure
8. 8
   أخرىthe residue was recrystallized

الإجراء التجريبي

In a mixture of 50 ml of saturated aqueous sodium. hydrogencarbonate solution and 50 ml of methanol was suspended 2.6 g of Compound 2 prepared in Example 1, and the suspension was heated under reflux for 30 minutes. The resulting mixture was concentrated under reduced pressure, and water was added to the residue. The resulting mixture was extracted with ethyl acetate, and the extract was dried over anhydrous magnesium sulfate. After concentration under reduced pressure, the residue was recrystallized to afford 1.23 g of the desired product.

المصدر