تفاعل #64706

معادلة التفاعل

Methyl isocyanide

2-methylbenzoyl chloride

hydrochloric acid

acetone

→

title compound

N-methyl-2-(2-tolyl)-2-oxoacetamide

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGthe mixture was stirred at room temperature for 1.5 hours for hydrolysis
2. 2
   استخلاصThe mixture was extracted with methylene chloride
3. 3
   غسيلwashed with water
4. 4
   أخرىdried
5. 5
   أخرىThe solvent was evaporated under reduced pressure

الإجراء التجريبي

Methyl isocyanide (0.84 ml) was added to 2-methylbenzoyl chloride (1.55 g). The mixture was stirred at 60° C. for 16 hours. Then, 5N hydrochloric acid (1.5 ml) and acetone (2 ml) were added, and the mixture was stirred at room temperature for 1.5 hours for hydrolysis. Then, water was added. The mixture was extracted with methylene chloride, washed with water and dried. The solvent was evaporated under reduced pressure to obtain the title compound as an oil (1.68 g).

المصدر