تفاعل #646239

معادلة التفاعل

PBr3

107

3-(6-bromo-2-fluoro-3-hydroxymethyl-phenoxy)-5-chloro-benzonitrile

→

96

المردود 60.0%

3-(6-Bromo-3-bromomethyl-2-fluoro-phenoxy)-5-chloro-benzonitrile

المردود 60.0%

المذيبات

DCM

DCM

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated in vacuo
2. 2
   workup.DISSOLUTIONThe residue was dissolved in EtOAc
3. 3
   غسيلwashed with saturated aqueous NaHCO3
4. 4
   تجفيفdried (MgSO4)
5. 5
   أخرىEvaporation of the volatile materials

الإجراء التجريبي

A solution of PBr3 (0.74 mL of a 1 M solution in DCM, 1.1 equiv) was added to a solution of 107 (0.24 g, 0.67 mmol) in DCM (5 mL). The mixture was stirred at RT for 1 h and then concentrated in vacuo. The residue was dissolved in EtOAc, washed with saturated aqueous NaHCO3, and dried (MgSO4). Evaporation of the volatile materials afforded 0.17 g (60%) of 96.

المصدر