تفاعل #646238

معادلة التفاعل

NaBH4

105

3-(6-bromo-2-fluoro-3-formyl-phenoxy)-5-chloro-benzonitrile

→

3-(6-bromo-2-fluoro-3-hydroxymethyl-phenoxy)-5-chloro-benzonitrile

المردود 47.2%

المذيبات

THF

MeOH

ظروف التفاعل

المعالجة

1. 1
   أخرىquenched by the addition of saturated aqueous NH4Cl
2. 2
   استخلاصThe aqueous mixture was extracted with EtOAc
3. 3
   غسيلthe organic solution was washed with water
4. 4
   أخرىevaporated
5. 5
   أخرىThe crude product was purified by SiO2 chromatography
6. 6
   غسيلeluting with an EtOAc/hexane gradient (20% to 50% EtOAc)

الإجراء التجريبي

NaBH4 (0.64 g, 1.5 equiv) was added portionwise to a stirred solution of 105 (4.0 g, 11.3 mmol) in a mixture of THF (20 mL) and MeOH (10 mL) at RT. The reaction mixture was stirred for 12 h, and quenched by the addition of saturated aqueous NH4Cl. The aqueous mixture was extracted with EtOAc, and the organic solution was washed with water and evaporated. The crude product was purified by SiO2 chromatography eluting with an EtOAc/hexane gradient (20% to 50% EtOAc) to afford 1.9 g (47%) of 3-(6-bromo-2-fluoro-3-hydroxymethyl-phenoxy)-5-chloro-benzonitrile (107) as a yellow oil.

المصدر