تفاعل #64621

معادلة التفاعل

1,2-Diaminobenzene

4-[3-(1-pyrrolidinyl)propoxy]benzaldehyde

sodium bisulfite

→

title compound

المردود 34.0%

2-[4-[3-(1-pyrrolidinyl)propoxy]phenyl]-1H-benzimidazole

المردود 34.0%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe mixture is filtered
2. 2
   أخرىevaporated
3. 3
   أخرىThe residue is recrystallized from hot ethyl acetate/ethanol

الإجراء التجريبي

1,2-Diaminobenzene (4.65 g), 4-[3-(1-pyrrolidinyl)propoxy]benzaldehyde (Step B) (10.0 g) and sodium bisulfite (4.60 g) are stirred at reflux in methanol (300 mL) for 14 hours. The mixture is filtered and evaporated. The residue is recrystallized from hot ethyl acetate/ethanol to give 4.68 g of the title compound as a yellow solid.

المصدر