تفاعل #64449

معادلة التفاعل

methyl iodide

4-aminomethyl-2'-(t-butoxycarbonyl)biphenyl

triethylamine

carbon disulfide

→

Methyl N-[[2'-(t-Butoxycarbonyl)biphenyl-4-yl]methyl]dithiocarbamate

المذيبات

methanol

methanol

methanol

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added dropwise over about 10 minutes
2. 2
   درجة الحرارةAfter 2.5 hours the solution was cooled in an ice-methanol bath
3. 3
   أخرىThe cooling bath was removed
4. 4
   تركيزAfter 2 hours the solution was concentrated at 25° C
5. 5
   أخرىThe residue was partitioned between 50 ml of ether plus 10 ml of CH2Cl2 and 50 ml of 0.2N HCl
6. 6
   غسيلThe organic phase was washed with 25 ml of saturated NaCl solution (aqueous)
7. 7
   تجفيفdried over MgSO4
8. 8
   ترشيحfiltered
9. 9
   تركيزconcentrated
10. 10
    أخرىCrystallization of the residual oil from ether
11. 11
    أخرىyielded 1.57 g (84%) of nearly colorless crystals, mp 127.5°-128.5° C., satisfactory purity by TLC in 4:1 hexane-EtOAc

الإجراء التجريبي

A solution of 1.415 g (5 mmole) of 4-aminomethyl-2'-(t-butoxycarbonyl)biphenyl and 751 μl (545 mg, 5.4 mmole) of triethylamine in 5 ml of methanol was stirred under N2 at room temperature as a solution of 342 μl (434 mg, 5.7 mmole) of carbon disulfide in 2 ml of methanol was added dropwise over about 10 minutes. After 2.5 hours the solution was cooled in an ice-methanol bath, and a solution of 311 μl (710 mg, 5 mmole) of methyl iodide in 2 ml of methanol was added dropwise over about 10 minutes. The cooling bath was removed, and the solution was allowed to warm to room temperature. After 2 hours the solution was concentrated at 25° C. The residue was partitioned between 50 ml of ether plus 10 ml of CH2Cl2 and 50 ml of 0.2N HCl. The organic phase was washed with 25 ml of saturated NaCl solution (aqueous), dried over MgSO4, filtered, and concentrated. Crystallization of the residual oil from ether yielded 1.57 g (84%) of nearly colorless crystals, mp 127.5°-128.5° C., satisfactory purity by TLC in 4:1 hexane-EtOAc; mass spectrum (FAB) m/e 374 (M+1)+.

المصدر