تفاعل #64426

معادلة التفاعل

1-bromopentane

3-Bromophenol

potassium carbonate

→

3-bromo-phenol

n-pentyl ether

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooled to room temperature
2. 2
   ترشيحfiltered
3. 3
   workup.ADDITIONThe filtrate is diluted with ether
4. 4
   غسيلwashed with water and brine
5. 5
   تجفيفAfter drying over magnesium sulfate
6. 6
   تركيزconcentrating
7. 7
   أخرىthe crude oil obtained
8. 8
   أخرىis chromatographed over silica gel
9. 9
   غسيلeluted with 3:2 hexane

الإجراء التجريبي

To a solution of 5.0 gm of 3-Bromophenol in 60 mls of dimethylformamide is added 6.0 gm of potassium carbonate followed by 4.3 ml of 1-bromopentane. This mixture is heated to 60° C. for 6 hours and then cooled to room temperature and filtered. The filtrate is diluted with ether and washed with water and brine. After drying over magnesium sulfate and concentrating, the crude oil obtained is chromatographed over silica gel, and eluted with 3:2 hexane:ether to yield 3-bromo-phenol, n-pentyl ether as a clear oil.

المصدر