تفاعل #64417

معادلة التفاعل

1-Bromopentane

resorcinol

potassium carbonate

→

3-pentyloxyphenol

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   ترشيحThis mixture is filtered through Celite
2. 2
   تركيزconcentrated under vacuum
3. 3
   استخلاصextracted 3 times with ether
4. 4
   غسيلThe combined extracts are washed with saturated sodium chloride
5. 5
   تجفيفdried over magnesium sulfate
6. 6
   ترشيحfiltered
7. 7
   تركيزconcentrated under vacuum
8. 8
   أخرىchromatographed on normal phase silica gel eluting with a 4:1 ratio of hexane

الإجراء التجريبي

A mixture of 24.8 ml of 1-Bromopentane, 66.0 g of resorcinol, and 41.5 g of potassium carbonate is stirred in 400 ml of anhydrous dimethylformamide at 60° C. for 17 hours. This mixture is filtered through Celite and concentrated under vacuum. The residue is taken up in water and extracted 3 times with ether. The combined extracts are washed with saturated sodium chloride, dried over magnesium sulfate, filtered, and concentrated under vacuum. The residue is flash chromatographed on normal phase silica gel eluting with a 4:1 ratio of hexane:ether to yield 3-pentyloxyphenol as a clear oil.

المصدر