تفاعل #64358

معادلة التفاعل

AcOEt

N-cyano -6-nitro-2,2-dimethyl-2H-1-benzopyran-4-carboximidic acid ethyl ester

cyclopropylamine

dichloromethane

→

N-cyano-N'-cyclopropyl-6-nitro-2,2-dimethyl-2H-1-benzopyran -4-carboxamidine

المردود 29.5%

المذيبات

n-hexane

ظروف التفاعل

المعالجة

1. 1
   أخرىrecrystallization
2. 2
   workup.ADDITIONfrom a mixture of acetone and n-hexane

الإجراء التجريبي

A mixture of 98 mg of N-cyano -6-nitro-2,2-dimethyl-2H-1-benzopyran-4-carboximidic acid ethyl ester, 30 mg of cyclopropylamine, and 1 ml of dichloromethane was stirred at room temperature for 1.5 hours. The reaction mixture was subjected to silica gel column chromatography (AcOEt:n-hexane=l:l) and then recrystallization from a mixture of acetone and n-hexane to obtain 30 mg of N-cyano-N'-cyclopropyl-6-nitro-2,2-dimethyl-2H-1-benzopyran -4-carboxamidine represented by formula shown below.

المصدر