تفاعل #64309

معادلة التفاعل

1-cyano-2-methoxybenzene

tributyltin azide

→

5-(2-methoxyphenyl)-2H-tetrazole

المردود 98.1%

المذيبات

diethyl ether

xylene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةunder reflux for hours
3. 3
   درجة الحرارةThe reaction mixture then was cooled
4. 4
   أخرىAnhydrous hydrochloric acid was bubbled into the mixture
5. 5
   أخرىa white precipitate formed
6. 6
   ترشيحThe precipitate was collected by suction filtration
7. 7
   غسيلwashed repeatedly with diethyl ether
8. 8
   أخرىDrying

الإجراء التجريبي

A mixture of 1-cyano-2-methoxybenzene (1.02 g, 7.7 mmol) and tributyltin azide (3.4 g, 10.0 mmol) in 3.0 mL of xylene was heated under reflux for hours. The reaction mixture then was cooled and diluted with diethyl ether. Anhydrous hydrochloric acid was bubbled into the mixture and a white precipitate formed. The precipitate was collected by suction filtration and washed repeatedly with diethyl ether. Drying gave 5-(2-methoxyphenyl)-2H-tetrazole (1.33 g, 7.55 mmol).

المصدر