تفاعل #642611

معادلة التفاعل

2-chloro-3-nitrothiophene

2-tert-butylphenol

K2CO3

→

crude desired product

2-(2-tert-Butylphenoxy)-3-nitrothiophene

المذيبات

NMP

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction was flushed with nitrogen
2. 2
   أخرىsealed
3. 3
   درجة الحرارةThe reaction was cooled to rt
4. 4
   workup.ADDITIONdiluted with EtOAc (˜150 mL)
5. 5
   غسيلwashed twice with saturated aqueous NaCl (2ט150 mL)
6. 6
   استخلاصThe aqueous washes were then back extracted with EtOAc
7. 7
   تجفيفThe combined organics were dried over MgSO4
8. 8
   ترشيحfiltered
9. 9
   تركيزconcentrated

الإجراء التجريبي

To a solution of 2-chloro-3-nitrothiophene (1.13 g, 6.93 mmol) in NMP (10 mL) in a pressure vessel was added 2-tert-butylphenol (1.04 g, 6.93 mmol) and K2CO3 (1.0 g, 10.1 mmol). The reaction was flushed with nitrogen, sealed and then heated to 105° C. for 48 h. The reaction was cooled to rt, diluted with EtOAc (˜150 mL) and washed twice with saturated aqueous NaCl (2ט150 mL). The aqueous washes were then back extracted with EtOAc. The combined organics were dried over MgSO4, filtered and concentrated to yield the crude desired product.

المصدر