تفاعل #64198

معادلة التفاعل

4-bromomethylbenzonitrile

sodium azide

water

→

4-azidomethylbenzonitrile

المردود 96.7%

المذيبات

1,3-dimethyl-2-imidazolidinone

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted twice with dichloromethane
2. 2
   غسيلwashed with water
3. 3
   تجفيفdried over sodium sulfate
4. 4
   تركيزconcentrated to dryness under vacuum
5. 5
   أخرىchromatographed on silica gel with hexane/ethyl acetate

الإجراء التجريبي

50 g of 4-bromomethylbenzonitrile is dissolved in 350 ml of 1,3-dimethyl-2-imidazolidinone and stirred at 25° for 2 hours with 32.5 g of sodium azide. The mixture is subsequently combined with 500 ml of water under ice cooling, extracted twice with dichloromethane, washed with water, dried over sodium sulfate, concentrated to dryness under vacuum, and chromatographed on silica gel with hexane/ethyl acetate, thus obtaining 39 g of 4-azidomethylbenzonitrile as a colorless liquid.

المصدر