تفاعل #6414

معادلة التفاعل

p-hydroxybenzoic acid

(-)-2-methylbutanol

sulfuric acid

→

ester

المردود 83.0%

2-methylbutyl 4-hydroxybenzoate

المردود 83.0%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   أخرىwhile removing the generated water out from the reaction system
2. 2
   غسيلSubsequently, the reaction solution was washed with water
3. 3
   أخرىto remove sulfuric acid out
4. 4
   أخرىThe reaction solution was then dried
5. 5
   تركيزconcentrated
6. 6
   أخرىthe concentrate was purified by column chromatography

الإجراء التجريبي

4.0 g of p-hydroxybenzoic acid and 12.5 g of (-)-2-methylbutanol were refluxed for 6 hours in toluene in the presence of sulfuric acid, while removing the generated water out from the reaction system. Subsequently, the reaction solution was washed with water to remove sulfuric acid out. The reaction solution was then dried and concentrated, and the concentrate was purified by column chromatography, to obtain 5.0 g of the objective ester compound (liquid state at room temperature, [α]D23 =4.9° (CHCl3)). (Yield: 83%)

المصدر