تفاعل #6413

معادلة التفاعل

p-hydroxybenzoic acid

(S)-(+)-3-methyl-1-pentanol

sulfuric acid

→

ester

المردود 80.7%

3-methylpentyl p-hydroxybenzoate

المردود 80.7%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   أخرىwhile removing out the generated water from the reaction system
2. 2
   غسيلSubsequently, the reaction solution was washed with water
3. 3
   أخرىto remove the sulfuric acid out
4. 4
   أخرىThe reaction solution was then dried
5. 5
   تركيزconcentrated
6. 6
   أخرىpurified by column chromatography

الإجراء التجريبي

13.7 g of p-hydroxybenzoic acid and 11.4 g of (S)-(+)-3-methyl-1-pentanol were refluxed for 10 hours in toluene in the presence of sulfuric acid, while removing out the generated water from the reaction system. Subsequently, the reaction solution was washed with water to remove the sulfuric acid out. The reaction solution was then dried, concentrated, and purified by column chromatography, to obtain 17.8 g of the objective ester compound (liquid state at room temperature ([α]D23 =+7.8° (CHCl3)). (Yield: 80%)

المصدر