تفاعل #641000

معادلة التفاعل

Piperazine-1-carboxylic acid benzyl ester

Benzoyl chloride

NEt3

→

desired compound

4-benzoyl-piperazine-1-carboxylic acid benzyl ester

المذيبات

DCM

DCM

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with water
2. 2
   تجفيفdried (Na2SO4)
3. 3
   أخرىevaporated off

الإجراء التجريبي

Piperazine-1-carboxylic acid benzyl ester (500 mg) was dissolved in DCM (5 ml) and the mixture was cooled down to 0° C. Benzoyl chloride (290 μl) and NEt3 (379 μl) were added. The mixture was stirred for 48 h, diluted with DCM, washed with water, dried (Na2SO4) and evaporated off. After HV, 650 mg of the desired compound were obtained.

المصدر