تفاعل #6410

معادلة التفاعل

p-hydroxybenzoic acid

(S)-(-)-2-methylbutanol

sulfuric acid

water

→

ester

المردود 83.0%

2-methylbutyl p-hydroxybenzoate

المردود 83.0%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   أخرىwas removed out
2. 2
   غسيلSubsequently, the reaction solution was washed with water
3. 3
   أخرىto remove sulfuric acid out
4. 4
   أخرىAfter the resulting solution was dried
5. 5
   تركيزconcentrated
6. 6
   أخرىthe concentrate was purified by column chromatography

الإجراء التجريبي

4.0 g of p-hydroxybenzoic acid and 12.5 g of (S)-(-)-2-methylbutanol were refluxed for 6 hours in toluene in the presence of sulfuric acid, while the generated water was removed out. Subsequently, the reaction solution was washed with water to remove sulfuric acid out. After the resulting solution was dried and concentrated, the concentrate was purified by column chromatography to obtain 5.0 g of the objective ester compound (liquid state at room temperature, [α]D23 =+4.9° (CHCl3)). (Yield: 83%)

المصدر