تفاعل #64083

معادلة التفاعل

(2S, 5S, 6S)-2-trichloromethyl-5,6-dimethyl-1,3-dioxan-4-one

sulfuric acid

2-propanol

→

isopropyl (2S, 3S)-2-methyl-3-hydroxybutanoate

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   استخلاصfollowed by ether extraction
2. 2
   تجفيفThe ether phase was dried over anhydrous sodium sulfate
3. 3
   workup.DISTILLATIONthe residue was subjected to distillation

الإجراء التجريبي

To 1.0 g of (2S, 5S, 6S)-2-trichloromethyl-5,6-dimethyl-1,3-dioxan-4-one obtained by procedure similar to Example 1-(7) were added 0.1 ml of concentrated sulfuric acid and 10 ml of 2-propanol, stirred at room temperature for one hour, and 20 ml of water was added followed by ether extraction. The ether phase was dried over anhydrous sodium sulfate and the residue was subjected to distillation to give 0.4 g of isopropyl (2S, 3S)-2-methyl-3-hydroxybutanoate of the following formula. ##STR51##

المصدر