تفاعل #640575

معادلة التفاعل

3-(2-Nitrobenzyl)-6-phenyl-[1,3]-oxazinan-2-one

ammonium chloride

water

→

3-(2-aminobenzyl)-6-phenyl-[1,3]-oxazinan-2-one

المردود 99.3%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto reflux for 1.5 hours
2. 2
   ترشيحthe reaction mixture was filtered with suction
3. 3
   استخلاصextracted with ethyl acetate
4. 4
   غسيلThe organic layer was washed with a saturated brine
5. 5
   تجفيفdried over anhydrous sodium sulfate

الإجراء التجريبي

3-(2-Nitrobenzyl)-6-phenyl-[1,3]-oxazinan-2-one (1.59 g, 5.10 mmol), iron powder (1.42 g, 25.4 mmol), ammonium chloride (0.14 g, 2.62 mmol) were suspended in ethanol (30 ml) and water (15 ml) and heated to reflux for 1.5 hours. After cooling to room temperature, the reaction mixture was filtered with suction and extracted with ethyl acetate. The organic layer was washed with a saturated brine and then dried over anhydrous sodium sulfate, and 3-(2-aminobenzyl)-6-phenyl-[1,3]-oxazinan-2-one (1.43 g) was obtained by evaporating the solvent under reduced pressure.

المصدر