تفاعل #640556

معادلة التفاعل

4,4′-dibromobenzil

o-phenylenediamine

→

2,3-bis(4-bromophenyl)quinoxaline

المردود 92.0%

المذيبات

chloroform

ظروف التفاعل

المعالجة

1. 1
   غسيلThe reaction solution was washed with water
2. 2
   درجة الحرارةafter being cooled to room temperature
3. 3
   استخلاصAn aqueous layer was extracted with chloroform
4. 4
   غسيلwashed with a saturated saline solution
5. 5
   تجفيفThe organic layer was dried over magnesium sulfate
6. 6
   ترشيحfiltered
7. 7
   أخرىcondensed

الإجراء التجريبي

A chloroform solution (200 mL) of 30.0 g (81.5 mmol) of 4,4′-dibromobenzil and 9.00 g (83.2 mmol) of o-phenylenediamine was heated and refluxed at 80° C. for 3 hours under nitrogen atmosphere. The reaction solution was washed with water after being cooled to room temperature. An aqueous layer was extracted with chloroform. This extracted aqueous layer and an organic layer were put together and washed with a saturated saline solution. The organic layer was dried over magnesium sulfate and filtered. The filtrate was condensed to obtain 33 g (yield: 92%) of objective 2,3-bis(4-bromophenyl)quinoxaline as a white solid. Synthetic scheme of Step 1 is shown in the following (d-1).

المصدر