تفاعل #640541

معادلة التفاعل

6-aminonicotinic acid

ethanol

→

white solid

Ethyl 6-Aminonicotinate

ظروف التفاعل

المعالجة

1. 1
   أخرىwas bubbled in dry hydrochloric acid at 0° C.
2. 2
   درجة الحرارةthe solution was refluxed until all the solids
3. 3
   workup.DISSOLUTIONdissolved
4. 4
   أخرىThe solvents were removed under reduced pressure
5. 5
   workup.DISSOLUTIONthe residue dissolved in ethyl acetate
6. 6
   غسيلwashed with saturated sodium bicarbonate, brine
7. 7
   تركيزconcentrated

الإجراء التجريبي

To a suspension of 1.3 g (9.4 mmol) 6-aminonicotinic acid in 100 mL of ethanol, was bubbled in dry hydrochloric acid at 0° C., then the solution was refluxed until all the solids dissolved. The solvents were removed under reduced pressure, the residue dissolved in ethyl acetate, washed with saturated sodium bicarbonate, brine and concentrated to afford 1.37 g of a white solid, m/e=166(M+H).

المصدر