تفاعل #640539

معادلة التفاعل

2,6-Dimethylaniline

ethyl bromoacetate

N-(2,6-Dimethylphenyl)glycine hydrobromide salt

→

N-(2,6 Dimethylphenyl)glycine

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىA precipitated
2. 2
   أخرىformed which
3. 3
   أخرىwas collected
4. 4
   أخرىtriturated with dichloromethane (25 mL)

الإجراء التجريبي

2,6-Dimethylaniline (6.1 g, 50.4 mmol), and ethyl bromoacetate (8.4 g, 50.4 mmol) were refluxed neat for 10 min. The reaction mixture was cooled to room temperature and poured into dichloromethane (75 mL). A precipitated formed which was collected and triturated with dichloromethane (25 mL). N-(2,6-Dimethylphenyl)glycine hydrobromide salt (1.21 g, 4.6 mmol, 9.0%) was collected as a white crystalline solid. 1H NMR (CD3OD) d 2.48 (s, 6H), 4.29 (s, 2H), 7.00-7.10 (m, 3H).

المصدر