تفاعل #640532

معادلة التفاعل

4-(1H-benzimidazol-2-yl)-furazan-3-ylamine

potassium carbonate

4-chloro-3-nitrophenacyl bromide

→

title compound

4-[1-(4-Chloro-3-nitrophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

المذيبات

DMF

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with water
2. 2
   تجفيفdried over sodium sulphate
3. 3
   ترشيحFiltration of the sodium sulphate, concentration of the filtrate under reduced pressure and chromatography of the residue on silicagel

الإجراء التجريبي

A suspension of 4-(1H-benzimidazol-2-yl)-furazan-3-ylamine (0.228 g, 1.14 mmol), potassium carbonate (0.40 g, 2.85 mmol) and 4-chloro-3-nitrophenacyl bromide (0.35 g, 1.25 mmol) in DMF (5 ml) is stirred at room temperature for 16 hours. The reaction mixture is diluted with ethyl acetate, washed with water and dried over sodium sulphate. Filtration of the sodium sulphate, concentration of the filtrate under reduced pressure and chromatography of the residue on silicagel using hexane-ethyl acetate as eluent gives the title compound as a solid, m.p. 198-200° C. (This compound is also listed as Example 66 in Table 1.)

المصدر