تفاعل #640531

معادلة التفاعل

4-[1-(4-chloro-3-nitrophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

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title compound

4-[1-(3-Amino-4-chlorophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

المذيبات

ethanol

water

ظروف التفاعل

المعالجة

1. 1
   ترشيحFiltration and evaporation at reduced pressure
2. 2
   أخرىgives the crude product
3. 3
   أخرىPurification
4. 4
   استخلاصby extraction with ethyl acetate and chromatography on silicagel

الإجراء التجريبي

To a stirred solution of 4-[1-(4-chloro-3-nitrophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine (0.07 g, 0.175 mmol) in ethanol (6 ml) and water (1 ml) is added two drops of concentrated hydrochloric acid and iron powder (0.1 g, 17.5 mmol). The reaction mixture is heated at 80° C. for 8 hours. Filtration and evaporation at reduced pressure gives the crude product. Purification by extraction with ethyl acetate and chromatography on silicagel yields the title compound as colorless solid, m.p. 228-230° C.

المصدر