تفاعل #640530

معادلة التفاعل

4-[1-(4-acetaminophenacyl)-1H-benzimidazol-2-yl]-furazan-3-yl-N-(2-cyanoethyl)-amine

sodium bicarbonate

→

title compound

4-[1-(4-Aminophenacyl)-1H-benzimidazol-2-yl]-furazan-3-yl-N-(2-carboxyethyl)-amine

المذيبات

water

hydrochloric acid

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux for two hours
2. 2
   استخلاصExtraction with ethyl acetate
3. 3
   تجفيفdrying over sodium sulphate
4. 4
   ترشيحfiltering
5. 5
   أخرىevaporation of the resulting filtrate to dryness

الإجراء التجريبي

A solution of 4-[1-(4-acetaminophenacyl)-1H-benzimidazol-2-yl]-furazan-3-yl-N-(2-cyanoethyl)-amine (0.061 g) in aqueous hydrochloric acid (5 ml, HCl conc.) is heated at reflux for two hours. The mixture is diluted with water and neutralized by addition of sodium bicarbonate. Extraction with ethyl acetate, drying over sodium sulphate, filtering and evaporation of the resulting filtrate to dryness gives the title compound in pure form, m.p. 174-177° C. 1H-NMR (400 MHz, d6-DMSO): 12.40 (s, 1H); 7.84 (m, 4H); 7.38 (m, 3H); 6.65 (m, 2H); 6.28 (S, 2H); 6.17 (s, 2H); 3.57 (m, 2H); 2.66 (t, 2H).

المصدر