تفاعل #640523

معادلة التفاعل

diiodomethane

4-(1H-benzimidazol-2-yl)-furazan-3-ylamine

potassium carbonate

4-fluorophenol

→

title compound

4-[1-(4-Fluorophenoxymethyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

ظروف التفاعل

المعالجة

1. 1
   أخرىEvaporation of the solvent under reduced pressure
2. 2
   أخرىpartitioning of the resulting residue between water and ethyl acetate
3. 3
   تجفيفby drying of the organic solution over sodium sulphate and chromatography of the residue

الإجراء التجريبي

To a solution of 4-(1H-benzimidazol-2-yl)-furazan-3-ylamine (0.10 g, 0.497 mmol) is added potassium carbonate (0.172 g, 1.24 mmol) followed by 4-fluorophenol (0.0557 g, 0.497 mmol) and diiodomethane (0.133 g, 0.497 mmol). The mixture is stirred over night. Evaporation of the solvent under reduced pressure and partitioning of the resulting residue between water and ethyl acetate followed by drying of the organic solution over sodium sulphate and chromatography of the residue gives the title compound as a colorless solid, m.p. 155-158° C.

المصدر