تفاعل #640522

معادلة التفاعل

4-(1H-benzimidazol-2-yl)-furazan-3-ylamine

potassium carbonate

iodomethoxy benzene

→

title compound

4-(1-Phenoxymethyl-1H-benzimidazol-2-yl)-furazan-3-ylamine

ظروف التفاعل

المعالجة

1. 1
   أخرىEvaporation of the solvent under reduced pressure
2. 2
   أخرىpartitioning of the resulting residue between water and ethyl acetate
3. 3
   تجفيفby drying of the organic solution over sodium sulphate and chromatography of the residue

الإجراء التجريبي

To a solution of 4-(1H-benzimidazol-2-yl)-furazan-3-ylamine (0.10 g, 0.497 mmol) is added potassium carbonate (0.172 g, 1.24 mmol) and iodomethoxy benzene (0.128 g, 0.546 mmol). The mixture is stirred over night. Evaporation of the solvent under reduced pressure and partitioning of the resulting residue between water and ethyl acetate followed by drying of the organic solution over sodium sulphate and chromatography of the residue gives the title compound as a colorless solid, m.p. 171-173° C.

المصدر