تفاعل #640517

معادلة التفاعل

4-[1-(4-bromophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

sodium bicarbonate

hydroxylamine hydrochloride

→

title compound

4-[1-(4-Bromophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine oxime

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةis refluxed for 20 hours
2. 2
   أخرىPartitioning of the reaction mixture between ethyl acetate and water, separation of the organic phase
3. 3
   أخرىby drying
4. 4
   أخرىevaporation of the solvent
5. 5
   أخرىgives the crude product
6. 6
   أخرىPurification by chromatography on silicagel

الإجراء التجريبي

A mixture of 4-[1-(4-bromophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine (0.083 g, 0.21 mmol, prepared according to Example 1), sodium bicarbonate (0.021 g, 0.25 mmol) and hydroxylamine hydrochloride (0.014 g, 0.21 mmol) in ethanol (5 ml) is refluxed for 20 hours. Partitioning of the reaction mixture between ethyl acetate and water, separation of the organic phase followed by drying and evaporation of the solvent gives the crude product. Purification by chromatography on silicagel yields the title compound as an E/Z-mixture, m.p. 198-201° C.

المصدر